[1]顾万君,马建民,周童,等.不同折叠类型蛋白编码基因的密码子使用[J].东南大学学报(自然科学版),2002,32(3):362-366.[doi:10.3969/j.issn.1001-0505.2002.03.011]
 Gu Wanjun,Ma Jianmin,Zhou Tong,et al.Codon usage in genes coding for proteins with different folding types[J].Journal of Southeast University (Natural Science Edition),2002,32(3):362-366.[doi:10.3969/j.issn.1001-0505.2002.03.011]
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不同折叠类型蛋白编码基因的密码子使用()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
32
期数:
2002年第3期
页码:
362-366
栏目:
生物医学工程
出版日期:
2002-05-20

文章信息/Info

Title:
Codon usage in genes coding for proteins with different folding types
作者:
顾万君 马建民 周童 孙啸 陆祖宏
东南大学吴健雄实验室,南京 210096
Author(s):
Gu Wanjun Ma Jianmin Zhou Tong Sun Xiao Lu Zuhong
Chien-Shiung Wu Laboratory,Southeast University,Nanjing 210096,China
关键词:
密码子偏性 蛋白质折叠类型 蛋白质二级结构预测 方差分析
Keywords:
codon usage bias protein folding type protein secondary structure prediction variance analysis
分类号:
Q52
DOI:
10.3969/j.issn.1001-0505.2002.03.011
摘要:
对195个编码不同折叠类型蛋白(50种全α结构蛋白,66种全β结构蛋白,37种α+β结构蛋白,42种α/β结构蛋白)基因的密码子使用偏性的方差分析研究表明,不同折叠类型蛋白的密码子使用偏性有着显著的区别.特定折叠类型的蛋白有着特定的编码基因的密码子使用模式.这一结果表明,在蛋白质折叠类型和蛋白质二级结构的预测过程中,编码基因的密码子使用偏性可以作为蛋白质一级结构以外的一项重要的预测标准.
Abstract:
195 genes coding for proteins in four different folding types have been analyzed in terms of variance analysis,in which there are 50 genes coding for all α proteins,66 entries for all β proteins,37 entries for α+β proteins and 42 entries for α/β proteins.It has been observed that codon usage in different gene classes coding for different folding proteins is significantly different.Similar to amino acid propensities in different protein classes,folding type-specific proteins have specific codon usage patterns.With the help of codon usage pattern, the prediction of protein folding type and further prediction of protein secondary structure can be improved.

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相似文献/References:

[1]顾万君,周童,马建民,等.不同折叠类型蛋白中基于密码子的二级结构偏向性分析[J].东南大学学报(自然科学版),2004,34(1):72.[doi:10.3969/j.issn.1001-0505.2004.01.017]
 Gu Wanjun,Zhou Tong,Ma Jianmin,et al.Codon-based amino acid propensities for secondary structural units in proteins with different folding types[J].Journal of Southeast University (Natural Science Edition),2004,34(3):72.[doi:10.3969/j.issn.1001-0505.2004.01.017]

备注/Memo

备注/Memo:
基金项目: 国家重大基础研究项目(G1998051200)、国家自然科学基金资助项目(69525102).
作者简介: 顾万君(1977—),男,博士生,wanjungu@seu.edu.cn; 陆祖宏(联系人),男,博士,教授,博士生导师,zhlu@seu.edu.cn.
更新日期/Last Update: 2002-05-20