[1]王正梅,李新松,哈涌泉.口服胰岛素缓释微球的制备[J].东南大学学报(自然科学版),2002,32(3):371-373.[doi:10.3969/j.issn.1001-0505.2002.03.013]
　Wang Zhengmei,Li Xinsong,Ha Yongquan.Preparation of oral insulin sustained-release microspheres[J].Journal of Southeast University (Natural Science Edition),2002,32(3):371-373.[doi:10.3969/j.issn.1001-0505.2002.03.013]
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口服胰岛素缓释微球的制备()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
32
期数:
2002年第3期
页码:
371-373
栏目:
生物医学工程
出版日期:
2002-05-20

文章信息/Info

Title:
Preparation of oral insulin sustained-release microspheres
作者:
王正梅;  李新松;  哈涌泉
东南大学化学化工系,南京 210096
Author(s):
Wang Zhengmei;  Li Xinsong;  Ha Yongquan
Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China
关键词:
胰岛素;  缓释微球;  糖尿病
Keywords:
insulin;  sustained-release microspheres;  diabetes
分类号:
R944.27
DOI:
10.3969/j.issn.1001-0505.2002.03.013
摘要:
用液中干燥法制备胰岛素的丙烯酸树脂缓释微球.利用扫描电镜和紫外光谱考察了内相聚合物浓度和搅拌速度对微球粒径和药物包封率的影响.结果表明,随着搅拌速度的增加和内相聚合物浓度的减小,微球粒径减小,药物包封率有所增加.此外,温度、投药量、分散剂对成球有一定的影响.最后,对缓释微球中胰岛素含量进行了测定.
Abstract:
Insulin-loaded polyacrylate sustained-release microspheres were prepared using liquid process. The effects of polymer concentration and agitation rates on the size of microspheres and drug incorporation efficiency were studied by scanning electronic microscopy(SEM)and UV-spectrophotometry. The results show that the mean diameter of microspheres decreases with the increase of stirring rate and the decrease of polymer concentration, meanwhile the drug loading efficiency increases with the increase of stirring rate. Besides, the content of emulsifier, temperature and drug payloads all have certain effects on microspheres formation. Finally, the content of insulin in the microspheres was determined.

参考文献/References:

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相似文献/References:

[1]周士新,谢建明,孙啸,等.不同物种间胰岛素及其编码mRNA,DNA序列比较与分析[J].东南大学学报(自然科学版),2003,33(3):292.[doi:10.3969/j.issn.1001-0505.2003.03.011]
　Zhou Shixin,Xie Jianming,Sun Xiao,et al.Comparison and analysis of insulin sequences and their coded mRNA and DNA among different species[J].Journal of Southeast University (Natural Science Edition),2003,33(3):292.[doi:10.3969/j.issn.1001-0505.2003.03.011]

备注/Memo

备注/Memo:
作者简介: 王正梅(1970—),女,硕士生; 李新松(联系人),男,博士,教授,XSLi@seu.edu.cn.
更新日期/Last Update: 2002-05-20