[1]谢建明,孙啸,谢雪英,等.基因表达模式分析及软件系统[J].东南大学学报(自然科学版),2003,33(2):201-204.[doi:10.3969/j.issn.1001-0505.2003.02.021]
 Xie Jianming,Sun Xiao,Xie Xueying,et al.Gene expression profile analysis and software system[J].Journal of Southeast University (Natural Science Edition),2003,33(2):201-204.[doi:10.3969/j.issn.1001-0505.2003.02.021]
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基因表达模式分析及软件系统()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
33
期数:
2003年第2期
页码:
201-204
栏目:
生物医学工程
出版日期:
2003-03-20

文章信息/Info

Title:
Gene expression profile analysis and software system
作者:
谢建明 孙啸 谢雪英 陆祖宏
东南大学分子与生物分子电子学教育部重点实验室,南京 210096
Author(s):
Xie Jianming Sun Xiao Xie Xueying Lu Zuhong
Education Ministry Key Laboratory of Molecular and Bio-molecular Electronics, Southeast University, Nanjing 210096, China
关键词:
基因表达模式 聚类分析 生物信息学软件 模糊聚类法
Keywords:
gene expression profile clustering analysis bioinformatics software fuzzy clustering algorithm
分类号:
Q52
DOI:
10.3969/j.issn.1001-0505.2003.02.021
摘要:
研究和实现了4种基因表达模式的聚类方法,开发了基因表达模式分析软件系统.该软件包含了两两平均连锁聚类法、系统聚类法、自组织特征映射法和模糊聚类等聚类算法,其中模糊聚类算法是首次用于基因表达模式分析.该软件同时具有数据过滤、多种相似性度量选择、聚类方法选择和结果可视化等功能.对于同一组基因表达数据,可通过不同的聚类算法的组合,提供更多的基因分类信息,为生物体复杂的基因表达模式研究提供了一个重要的综合分析平台.
Abstract:
A software package for gene expression profile analysis has been constructed. The kernel of the software consists of 4 clustering algorithms including pair-wise average linkage analysis, hierarchical clustering, self-organization feature mapping, and fuzzy clustering which is first applied in the field. Other tools have been integrated into the software, such as data preprocessing, similarity measurement function selection and data visualization. For the same dataset of gene expression profile, this software has been shown as a useful integrated platform to delve into the complex regulatory mechanism based on expression data of organisms.

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备注/Memo

备注/Memo:
基金项目: 国家863资助项目(2002AA231071)、东南大学科学基金资助项目(9207031090).
作者简介: 谢建明(1971—),男,讲师,xiejm@seu.edu.cn; 孙啸(联系人),男,博士,教授,xsun@seu.edu.cn.
更新日期/Last Update: 2003-03-20