[1]路新丽,张东生,顾宁,等.肿瘤热疗用锰锌铁氧体纳米粒的制备及表征[J].东南大学学报(自然科学版),2004,34(1):82-84.[doi:10.3969/j.issn.1001-0505.2004.01.019]
 Lu Xinli,Zhang Dongsheng,Gu Ning,et al.Preparation and characterization of Mn-Zn ferrite nanoparticles for tumor hyperthermia[J].Journal of Southeast University (Natural Science Edition),2004,34(1):82-84.[doi:10.3969/j.issn.1001-0505.2004.01.019]
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肿瘤热疗用锰锌铁氧体纳米粒的制备及表征()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
34
期数:
2004年第1期
页码:
82-84
栏目:
电气工程
出版日期:
2004-01-20

文章信息/Info

Title:
Preparation and characterization of Mn-Zn ferrite nanoparticles for tumor hyperthermia
作者:
路新丽1 张东生1 顾宁2 郑杰1 朱伟长3 金立强1 万美玲1
1 东南大学基础医学院, 南京 210009; 2 东南大学生物科学与医学工程系, 南京 210096; 3 安徽工业大学化工与环境学院, 马鞍山 243002
Author(s):
Lu Xinli1 Zhang Dongsheng1 Gu Ning2 Zheng Jie1 Zhu Weichang3 Jin Liqiang1 Wan Meiling1
1 School of Basic Medical Science, Southeast University, Nanjing 210009, China
2 Department of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
3 School of Chemical Engineerin
关键词:
锰锌铁氧体 纳米粒 肿瘤热疗
Keywords:
Mn-Zn ferrite nanoparticles tumor hyperthermia
分类号:
TM277.1
DOI:
10.3969/j.issn.1001-0505.2004.01.019
摘要:
以硫酸盐为原料, NaOH为沉淀剂制备了一系列MnxZn1-xFe2O4纳米粒(x=0.1,0.3,…,0.9,1.0),对其进行了X-射线衍射分析,证实其为尖晶石型锰锌铁氧体; 透射电镜观察其形貌为近似球状; 图像分析仪测算其平均粒径为30 nm; 并进行了居里温度测定和给定交变磁场下的体外升温、恒温实验,结果显示所制备材料的居里温度随锌含量的增加而降低; 在相同介质、相同质量浓度条件下,其相应磁流体体外升温实验所能达到的恒定温度亦随锌含量的增加而降低, 如在磁流体质量浓度为20 g/L时,其恒定时的温度在68~40 ℃之间.实验结果为进一步筛选出适合肿瘤热疗的材料配比及相应的质量浓度提供了理论及实验依据.
Abstract:
With the sulfate as the materials and NaOH as precipitator, a series of MnxZn1-xFe2O4 nanoparticles(x=0.1, 0.3, …, 0.9, 1.0)were produced, which are proved to be spinel Mn-Zn ferrite analyzed by X-ray diffraction(XRD). Their shapes are approximately global examined by transmission electron microscopy(TEM)and their average diameter is 30 nm measured with image analysis system. The curie temperature was measured and in vitro heating test in a given alternating magnetic field was carried out.The results show that the curie temperature increases with the reduction of the content of Zn and the steady temperature of the corresponding magnetic fluid in in vitro heating test also increases along with the reduction of the content of Zn at 20 g/L. The steady temperature is between 40 ℃ and 68 ℃. The results provide theoretical and practical evidence to select an appropriate value of x suitable for tumor hyperthermia.

参考文献/References:

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[4] 朱伟长,张东生,潘峰.Zn0.5Ni0.5Fe2O4纳米粉体材料的制备及分散性研究 [J].东南大学学报(自然科学版),2003,3(2):241-244.
  Zhu Weichang,Zhang Dongsheng,Pan Feng.Preparation and dispersion of nanoscale Zn0.5Ni0.5Fe2O4 ferrite powders [J].Journal of Southeast University(Natural Science Edition),2003,3(2):241-244.(in Chinese)
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备注/Memo

备注/Memo:
基金项目: 国家高技术研究发展计划(863计划)资助项目(2002AA302207)、江苏省自然科学基金资助项目(BK2001003)、江苏省中医药、中西医结合重点资助项目(H027)、东南大学科学基金资助项目(9223001162)、国家自然科学基金资助项目(30371830).
作者简介: 路新丽(1975—),女,硕士生; 张东生(联系人),男,教授,b7712900@jlonline.com.
更新日期/Last Update: 2004-01-20