[1]郭超,董寅生,林萍华,等.聚乳酸多孔支架的制备研究[J].东南大学学报(自然科学版),2004,34(4):495-499.[doi:10.3969/j.issn.1001-0505.2004.04.016]
 Guo Chao,Dong Yinsheng,Lin Pinghua,et al.Study on fabrication of poly(lactic acid)porous scaffolds[J].Journal of Southeast University (Natural Science Edition),2004,34(4):495-499.[doi:10.3969/j.issn.1001-0505.2004.04.016]
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聚乳酸多孔支架的制备研究()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
34
期数:
2004年第4期
页码:
495-499
栏目:
生物医学工程
出版日期:
2004-07-20

文章信息/Info

Title:
Study on fabrication of poly(lactic acid)porous scaffolds
作者:
郭超1 董寅生1 林萍华1 3 浦跃朴2 刘斌1
1 东南大学材料科学与工程系, 南京 210096; 2 东南大学公共卫生学院, 南京 210009; 3 河海大学材料科学与工程系, 南京 210098
Author(s):
Guo Chao1 Dong Yinsheng1 Lin Pinghua1 3 Pu Yuepu2 Liu Bin1
1 Department of Materials Science and Engineering, Southeast University, Nanjing 210096, China
2 School of Public Health, Southeast University, Nanjing 210009, China
3 Department of Materials Science and Engineerin
关键词:
组织工程 粒子滤出 冷冻干燥 多孔支架
Keywords:
tissue engineering porogen-leaching freeze-drying porous scaffolds
分类号:
R318.08
DOI:
10.3969/j.issn.1001-0505.2004.04.016
摘要:
分别采用粒子滤出法和冷冻干燥-粒子滤出复合法制备了聚乳酸多孔支架.在粒子滤出法中,采用氯化钠和碳酸氢铵作为造孔剂制备多孔支架; 在冷冻干燥法中,采用碳酸氢铵和冰颗粒作为造孔剂制备多孔支架.实验结果表明:采用氯化钠或碳酸氢铵做造孔剂,生成的多孔支架有造孔剂残留; 采用冰颗粒造孔则无残留.研究认为,采取适当的工艺措施,加速造孔剂向环境的传质过程,是降低支架中造孔剂残留的有效途径,并提出了在实际中可采取的改进措施,包括选用易于滤出的材料、提高氯仿和造孔剂含量、提高温度和真空度、采用特殊气氛、提高过滤溶液的流动性.
Abstract:
Porous poly(l-lactic acid)(PLLA)scaffolds were fabricated using porogen-leaching and freeze-drying combined porogen-leaching process. The scaffolds prepared by porogen-leaching used sodium chloride or ammonium bicarbonate particles as porogen material, while the scaffolds prepared by freeze-drying combined porogen-leaching process used ammonium bicarbonate or ice particles as porogen material. The experimental results show that these are remains in porous scaffolds when sodium chloride or ammonium bicarbonate particles is used as porogen material, however no remains exist in scaffolds when ice particles is used. The effective method to reduce the remains in porous scaffold is to speed up the transfer process of porogen to environment by proper technologies. Some practical methods are suggested: choosing porogen material which can be leached out easily; increasing the amount of chloroform and porogen; increasing temperature and degree of vacuum; choosing special gas; increasing fluidity of solution used to leach out porogen.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目: 江苏省高技术研究计划资助项目(BG2001033).
作者简介: 郭超(1976—),男,博士生; 董寅生(联系人),男,博士,副教授,dongys@seu.edu.cn.
更新日期/Last Update: 2004-07-20