[1]刘朝红,董寅生,林萍华,等.β-磷酸钙多孔生物陶瓷支架的制备及生物相容性[J].东南大学学报(自然科学版),2004,34(5):665-668.[doi:10.3969/j.issn.1001-0505.2004.05.023]
　Liu Chaohong,Dong Yinsheng,Lin Pinghua Zhang Qingguo,et al.Preparation and biocompatibility of porous β-Ca3(PO4)2 scaffold[J].Journal of Southeast University (Natural Science Edition),2004,34(5):665-668.[doi:10.3969/j.issn.1001-0505.2004.05.023]
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β-磷酸钙多孔生物陶瓷支架的制备及生物相容性()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
34
期数:
2004年第5期
页码:
665-668
栏目:
化学化工
出版日期:
2004-09-20

文章信息/Info

Title:
Preparation and biocompatibility of porous β-Ca3(PO4)2 scaffold
作者:
刘朝红1;  董寅生1;  林萍华1; 3;  章庆国2;  浦跃朴2;  刘斌1;  郭宗科2
1 东南大学材料科学与工程系, 南京 210096; 2 东南大学基础医学院, 南京 210009; 3 河海大学材料科学与工程系, 南京 210098
Author(s):
Liu Chaohong1;  Dong Yinsheng1;  Lin Pinghua1; 3 Zhang Qingguo2;  Pu Yuepu2;  Liu Bin1;  Guo Zongke2
1 Department of Materials Science and Engineering, Southeast University, Nanjing 210096, China
2 School of Basic Medical Science, Southeast University, Nanjing 210009, China
3 Department of Materials Science and En
关键词:
骨组织工程;  多孔;  β-TCP;  支架;  生物相容性
Keywords:
bone tissue engineering;  porous;  β-TCP;  scaffold;  biocompatibility
分类号:
TQ174.75
DOI:
10.3969/j.issn.1001-0505.2004.05.023
摘要:
以制备高性能骨组织工程支架为目的,利用直接沉淀法合成β-磷酸钙(β-TCP)粉末,将粉末与Al2O3-MgO-H3PO4粘结剂按一定比例调和成浆料,采用有机泡沫浸渍法使其成型,低温烘干后,升温至900～1 200 ℃烧结制得多孔β-TCP支架,通过体外细胞培养实验评价其生物相容性.研究表明,利用Al2O3-MgO-H3PO4作粘结剂,采用有机泡沫浸渍法制备的β-TCP支架孔隙率高,孔径大,具有开孔网状结构,而且无细胞毒性,生物相容性较好.
Abstract:
The subject of this paper is to produce scaffold of bone tissue engineering with good performance. The β-TCP(tricalcium phosphate)powders prepared by direct precipitation were mixed with appropriate amount of Al2O3-MgO-H3PO4 based binder to prepare the slurry. The porous scaffold was formed using foam impregnation process. Then the green samples were dried at low temperature. Finally they were sintered up to 900-1 200 ℃ to produce porous β-TCP scaffolds. The biocompatibility of the porous β-TCP was evaluated in vitro. The investigation shows that the porous β-TCP scaffold made by foam impregnation process with Al2O3-MgO-H3PO4 as the binder has big pores, high porosity, opening network configuration and good biocompatibility.

参考文献/References:

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相似文献/References:

[1]章庆国,赵士芳,郭宗科,等.纳米相陶瓷支架与人成骨细胞生物相容性的体外实验研究[J].东南大学学报(自然科学版),2004,34(2):219.[doi:10.3969/j.issn.1001-0505.2004.02.018]
　Zhang Qingguo,Zhao Shifang,Guo ZongkeDong Yinsheng,et al.Research of biocompatibility of nano-bioceramics using human periosteum in vitro[J].Journal of Southeast University (Natural Science Edition),2004,34(5):219.[doi:10.3969/j.issn.1001-0505.2004.02.018]

备注/Memo

备注/Memo:
基金项目: 江苏省高技术研究资助项目(2001033)、日本板梢子公司海外资金研究资助项目.
作者简介: 刘朝红(1978—),女,硕士生; 董寅生(联系人),男,副教授,dongys@seu.edu.cn.
更新日期/Last Update: 2004-09-20