[1]孙卫斌,吴亚菲,丁一,等.纳米羟基磷灰石对人牙周膜细胞增殖活性的影响[J].东南大学学报(自然科学版),2004,34(6):802-805.[doi:10.3969/j.issn.1001-0505.2004.06.019]
 Sun Weibin,Wu Yafei,Ding Yi,et al.Influence of nanophase hydroxyapatite on behavior of periodontal ligament cells[J].Journal of Southeast University (Natural Science Edition),2004,34(6):802-805.[doi:10.3969/j.issn.1001-0505.2004.06.019]
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纳米羟基磷灰石对人牙周膜细胞增殖活性的影响()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
34
期数:
2004年第6期
页码:
802-805
栏目:
生物医学工程
出版日期:
2004-11-20

文章信息/Info

Title:
Influence of nanophase hydroxyapatite on behavior of periodontal ligament cells
作者:
孙卫斌1 吴亚菲1 丁一1 储成林2 刘天佳1
1 四川大学华西口腔医学院, 成都 610064; 2 东南大学材料科学与工程系, 南京 210096
Author(s):
Sun Weibin1 Wu Yafei1 Ding Yi1 Chu Chenglin2 Liu Tianjia1
1 West China College of Stomatology, Sichuan University, Chengdu 610041, China
2 Department of Materials Science and Engineering, Southeast University, Nanjing 210096, China
关键词:
羟基磷灰石 纳米材料 牙周病
Keywords:
hydroxyapatite nanoparticle material periodontal disease
分类号:
R322.41
DOI:
10.3969/j.issn.1001-0505.2004.06.019
摘要:
采用溶胶-凝胶法合成纳米羟基磷灰石,透射电镜分析表明其为纳米尺度的材料.应用MTT法对纳米羟基磷灰石和致密羟基磷灰石对体外培养的牙周膜细胞生长进行了分析.结果表明,应用第2,3,4天纳米羟基磷灰石对牙周膜细胞增殖活性有明显促进作用,而致密羟基磷灰石与空白对照组无显著性差异,这说明纳米羟基磷灰石在促进牙周组织再生中有一定的意义.
Abstract:
With sol-gel method, the nanophases hydroxyapatite powders were fabricated. These powders were showed to be nanopaticles under transmission electron microscope. The effects on proliferation of periodontal ligament cell(PDLC)were observed in vitro with MTT[3-(4, 5-dimethylthiazo; -2-yl)-2, 5-diphenytetralium bromide] method. The results show that after 2, 3, 4 days treatment with nanoparticles of hydroxyapatite, the proliferative activity of the PDLC increases significantly.In contrast, there is no significant difference between dense hydroxyapatite and control group. Thus, the findings imply that nanophase hydroxyapatite can promote the regeneration of periodontal tissue.

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备注/Memo

备注/Memo:
基金项目: 江苏省社会发展基金资助项目(BS2003657)、南京医科大学创新基金资助项目(CX2003006).
作者简介: 孙卫斌(1960—),男,博士生,教授; 刘天佳(联系人),女,教授,博士生导师,yafeiwu@tom.com.
更新日期/Last Update: 2004-11-20