[1]周正东,舒华忠,P. Haigron,等.一种周围血管内放射治疗计划的优化方法[J].东南大学学报(自然科学版),2005,35(4):607-610.[doi:10.3969/j.issn.1001-0505.2005.04.024]
 Zhou Zhengdong,Shu Huazhong,P. Haigron,et al.Optimization of intravascular brachytherapy treatment planning in peripheral arteries[J].Journal of Southeast University (Natural Science Edition),2005,35(4):607-610.[doi:10.3969/j.issn.1001-0505.2005.04.024]
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一种周围血管内放射治疗计划的优化方法()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
35
期数:
2005年第4期
页码:
607-610
栏目:
生物医学工程
出版日期:
2005-07-20

文章信息/Info

Title:
Optimization of intravascular brachytherapy treatment planning in peripheral arteries
作者:
周正东1 舒华忠2 P. Haigron3 於文雪2 罗立民2
1 南京航空航天大学医学物理系, 南京 210016; 2 东南大学影像科学与技术实验室, 南京 210096; 3 雷恩第一大学信号与图像处理实验室, 法国 雷恩 35042
Author(s):
Zhou Zhengdong1 Shu Huazhong2 P. Haigron3 Yu Wenxue2 Luo Limin2
1 Department of Medical Physics, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
2 Laboratory of Image Science and Technology, Southeast University, Nanjing 210096, China
3 Laboratory of T
关键词:
周围血管内放射 主动漫游 剂量优化 BFGS算法 模拟退火算法
Keywords:
intravascular brachytherapy in peripheral arteries active navigation dose optimization BFGS algorithm simulated annealing algorithm
分类号:
R815;TP391
DOI:
10.3969/j.issn.1001-0505.2005.04.024
摘要:
为了促进内放射治疗技术尽早运用到PTA术后周围血管再狭窄的治疗中去,提出一种基于主动漫游的周围血管内放射治疗计划的混合优化方法。首先利用主动漫游获取血管的几何结构,然后建立数学模型对治疗计划方案进行优化。为了加快优化速度,根据待优化参数的属性,综合运用BFGS算法和模拟退火算法来进行优化。实验结果表明, 采用上述方法得到了较好的剂量表面直方图,等处方剂量线与治疗区血管内表面吻合良好,并具有较快的计算速度.
Abstract:
In order to promote the technology of intravascular brachytherapy to be applied timely in the restenosis treatment of peripheral arteries after percutaneous transluminal angioplasty(PTA), a method combining the active navigation with optimization algorithm for the planning of peripheral intravascular brachytherapy is proposed. According to the characteristics of the vessel obtained by active navigation, a method combining the broyden-fletcher-goldfarb-shanno(BFGS)with simulated annealing algorithm is applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and animal models of stenosis shows that qualified dose surface histogram(DSH)could be obtained within a few minutes, the iso-prescribe-dose line fits well to the inner surface of vascular within treatment region.

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备注/Memo

备注/Memo:
作者简介: 周正东(1969—),男,博士,讲师,zzd_msc@nuaa.edu.cn.
更新日期/Last Update: 2005-07-20