[1]申祥,倪中华.生物可降解镁合金支架的扩张性能[J].东南大学学报(自然科学版),2008,38(1):49-53.[doi:10.3969/j.issn.1001-0505.2008.01.010]
 Shen Xiang,Ni Zhonghua.Expansion behaviour of biodegradable magnesium-alloy stent[J].Journal of Southeast University (Natural Science Edition),2008,38(1):49-53.[doi:10.3969/j.issn.1001-0505.2008.01.010]
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生物可降解镁合金支架的扩张性能()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
38
期数:
2008年第1期
页码:
49-53
栏目:
生物医学工程
出版日期:
2008-01-20

文章信息/Info

Title:
Expansion behaviour of biodegradable magnesium-alloy stent
作者:
申祥 倪中华
东南大学机械工程学院,南京 211189
Author(s):
Shen Xiang Ni Zhonghua
School of Mechanical Engineering, Southeast University, Nanjing 211189, China
关键词:
生物可降解 镁合金支架 非线性有限元 体外扩张
Keywords:
biodegradable magnesium-alloy stent nonlinear finite element in vitro expansion
分类号:
R318.01;R318.11
DOI:
10.3969/j.issn.1001-0505.2008.01.010
摘要:
介绍了生物可降解镁合金支架的应用背景和研究现状.应用有限元方法研究了镁合金支架的扩张过程.为了便于分析和比较,同时建立了具有相同几何模型的316L医用不锈钢支架,分别比较了它们在几何变形、应力分布、轴向缩短率、扩张速度等方面的差异性.结果显示,扩张镁合金支架比扩张不锈钢支架要容易得多.在扩张压力和扩张直径相同的前提下扩张镁合金支架和不锈钢支架,前者的扩张速度高于后者; 前者的轴向缩短率小于后者; 扩张到最大直径时,前者的最大Von Mises应力小于后者.有限元模拟对支架性能的评价和设计有一定指导意义.
Abstract:
The application background and research overview of biodegradable magnesium-alloy stent(BMS)are presented. A finite element modeling(FEM)was applied to study the expansion of BMS. A model of 316L stainless steel stent(SSS)with the same geometry parameter was also studied and mechanical parameters of both models were researched and compared, including geometry deformation, stress distribution, foreshortening and expansion velocity. The results show that BMS is much easier to expand than SSS. With same expanision pressure and expansion diameter, the expanding velocity of BMS is higher than that of SSS when expanded by balloon. Foreshortening of the former is smaller than that of the latter. Biggest Von Mises stress of BMS is lower than that of SSS when expanding to maximal diameter. In conclusion, FEM can quantify some mechanical behavior of stent and help designers to optimize stent system.

参考文献/References:

[1] Serruys P W,Jaegere P D,Kiemeneij F,et al.A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery diease [J]. New England Journal of Medicine,1994,331(8):489-495.
[2] Hofma S H,Whelan D M C,van Beusekom H M M,et al.Increasing arterial wall injury after long-term implantation of two types of stent in a porcine coronary model [J]. European Heart Journal,1998,19(4):601-609.
[3] Waksman R,Pakala R,Kuchulakanti P K,et al.Safety and efficacy of bioabsorbable magnesium alloy stents in porcine coronary arteries [J].Catheterization and Cardiovascular Interventions,2006, 68(4):607-617.
[4] Mario C D,Griffiths H,Goktekin O,et al.Drug-eluting bioabsorbable magnesium stent [J].Journal of Interventional Cardiology,2004,17(6):391-395.
[5] Heublein B,Rohde R,Kaese V,et al.Biocorrosion of magnesium alloys:a new principle in cardiovascular implant technology? [J].Heart,2003,89(6):651-656.
[6] Peeters P,Bosiers M,Verbrist J,et al.Preliminary results after application of absorbable metal stents in patients with critical limb ischemia [J].Journal of Endovascular Therapy,2005,12(1):1-5.
[7] Eggebrecht H,Rodermann J,Hunold P,et al.Images in cardiovascular medicine.Novel magnetic resonance-compatible coronary stent:the absorbable magnesium alloy stent [J]. Circulation, 2005,112(18):e303-e304.
[8] Wang W Q,Liang D K,Yang D Z,et al.Analysis of the transient expansion behavior and design optimization of coronary stents by finite element method [J]. Journal of Biomechanics,2006, 39(1):21-32.
[9] Wu W,Yang D Z,Qi M,et al.An FEA method to study flexibility of expanded coronary stents [J].Journal of Materials Processing Technology,2007,184(1/2/3):447-450.
[10] Johnston B M,Johnston P R,Corney S,et al.Non-Newtonian blood flow in human right coronary arteries:transient simulations [J].Journal of Biomechanics,2006,39(6):1116-1128.
[11] Hallquist J O.LS-DYNA3D theoretical manual [M].Livermore CA:Livermore Software Technology Corporation,1993.
[12] Chua S N D,MacDonald B J,Hashmi M S J.Finite-element simulation of stent expansion [J]. Journal of Materials Processing Technology,2002,120(1/2/3):335-340.
[13] Etave F,Finet G,BOivin M,et al.Mechanical properties of coronary stents determined by using finite element analysis [J].Journal of Biomechanics,2001, 34(8):1065-1075.
[14] Migliavacca F,Petrini L,Montanari V,et al.A predictive study of the mechanical behavior of coronary stents by computer modeling [J].Medical Engineering & Physics,2005, 27(1):13-18.

备注/Memo

备注/Memo:
作者简介: 申祥(1980—),男,博士生; 倪中华(联系人),男,博士,教授,nzh2003@seu.edu.cn.
基金项目: 国家自然科学基金资助项目(50675033)、江苏省自然科学基金资助项目(BK2006709)、教育部科学技术研究重点资助项目(106083).
引文格式: 申祥,倪中华.生物可降解镁合金支架的扩张性能[J].东南大学学报:自然科学版,2008,38(1):49-53.
更新日期/Last Update: 2008-01-20