Xue Yuying,Tang Meng.Research progresses in biological effects of nanosilver[J].Journal of Southeast University (Natural Science Edition),2009,39(6):1315-1320.[doi:10.3969/j.issn.1001-0505.2009.06.043]





Research progresses in biological effects of nanosilver
薛玉英 唐萌
东南大学公共卫生学院, 南京 210009
Xue Yuying Tang Meng
School of Public Health,Southeast University,Nanjing 210009,China
纳米银 暴露途径 生物学效应
nanosilver routes of exposure biological effects
The research progresses in toxicological and biological effects of nanosilver are summarized. The physiochemical properties of nanosilver particles, the nanosilver’s entry portals into human bodies, and the interactions between nanosilver and tissues through different routes of exposure such as respiratory tract, skin and gastrointestinal tract are analyzed. It is pointed out that with the development and application of nanosilver products, the attention to possible negative biological effects of nanosilver products should be paid. Integrial and matter-of-fact data for comprehensive toxicological assessment is needed. The studies on cytotoxicity show that nanosilver can interact with thiol groups of proteins and enzymes, which causes the dysfunction of mitochondria, membrane permeability and apoptosis-like change of cell morphology. The mechanism of the cytotoxicity is not clear yet. Oxidative stress and lipoperoxidation might mediate the cytotoxicity of nanosilver. Therefore, with the strengthening of the studies on toxicological and biological effects of nanosilver, standard methods and evaluation systems on the biological safety assessment of nano-products should be established. Moreover, possible environmental problems should be concerned. Special biological and environmental effects caused by nanosilver should be further studied.


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作者简介: 薛玉英(1965—),女,博士,教授, yyxue@seu.edu.cn.
基金项目: 国家重大基础研究发展计划(973计划)资助项目(2006CB705602)、国家自然科学基金资助项目(30671782).
引文格式: 薛玉英,唐萌.纳米银生物学效应研究进展[J].东南大学学报:自然科学版,2009,39(6):1315-1320. [doi:10.3969/j.issn.1001-0505.2009.06.043]
更新日期/Last Update: 2009-11-20