[1]焦真,刘娜,陈志明.两亲嵌段聚合物载药胶束的绿色制备技术[J].东南大学学报(自然科学版),2010,40(5):1009-1012.[doi:10.3969/j.issn.1001-0505.2010.05.024]
 Jiao Zhen,Liu Na,Chen Zhiming.Green synthesis method of drug-loaded micelles based on amphiphilic diblock copolymer[J].Journal of Southeast University (Natural Science Edition),2010,40(5):1009-1012.[doi:10.3969/j.issn.1001-0505.2010.05.024]
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两亲嵌段聚合物载药胶束的绿色制备技术()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
40
期数:
2010年第5期
页码:
1009-1012
栏目:
化学化工
出版日期:
2010-09-20

文章信息/Info

Title:
Green synthesis method of drug-loaded micelles based on amphiphilic diblock copolymer
作者:
焦真 刘娜 陈志明
东南大学化学化工学院,南京 211189
Author(s):
Jiao Zhen Liu Na Chen Zhiming
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189,China
关键词:
超临界二氧化碳挥发法 两亲嵌段聚合物 紫杉醇 胶束 控制释药
Keywords:
supercritical carbon dioxide evaporation method amphiphilic diblock copolymer paclitaxel micell controlled drug release
分类号:
TQ469
DOI:
10.3969/j.issn.1001-0505.2010.05.024
摘要:
为了避免制备过程中有机溶剂的使用,开发了一种两亲嵌段聚合物载药胶束的新型绿色制备法——超临界二氧化碳挥发法,在自制的实验装置中成功制备了聚(2-甲基丙烯酰氧乙基磷酰胆碱)-聚甲基丙烯酸正丁酯(PMPC-b-PBMA)载紫杉醇胶束.该胶束具有较规则的球形形貌和较小的粒径分布,平均粒径为54nm,药物的包封率和载药量分别为61.0%和12.2%,与有机溶剂挥发法制备的胶束相当.体外释药动力学研究结果表明,该胶束可在人体血液环境中平缓释药,132h内的释药量达到55%,远高于采用有机溶剂挥发法制得的胶束.超临界二氧化碳挥发法有望成为缓释药物体系的新型制备法.
Abstract:
A novel green method for fabricating amphiphilic diblock copolymers micelles, the supercritical carbon dioxide evaporation method, is developed to avoid the usage of organic solvents during the preparation.The paclitaxel-loaded polymeric micelles composed of poly(n-butyl methacrylate)-b-poly(2-methacryloyloxyethyl phosphorylcholine)(PMPC-b-PBMA)are successfully prepared in a set of self-made equipment. The micelles have a regular spherical shape and a narrow size distribution. The mean diameter is 54nm. The drug encapsulation efficiency and the drug loading content of the micelles are 61.0% and 12.2%, respectively, which are similar to those of the micelles prepared by the organic solvent evaporation method. The results of the in vitro release kinetics study of paclitaxel from the micelles indicate that 55% of the paclitaxel is released from the micelles within 132h, which is much higher than the micelles prepared by the organic solvent evaporation method. Therefore, the supercritical carbon dioxide evaporation method has potential application in the preparation of controlled drug release systems.

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备注/Memo

备注/Memo:
作者简介: 焦真(1979—),男,博士,讲师; 陈志明(联系人),男,博士,教授,博士生导师,chenzm@seu.edu.cn.
基金项目: 江苏省高技术研究计划资助项目(BG2006038).
引文格式: 焦真,刘娜,陈志明.两亲嵌段聚合物载药胶束的绿色制备技术[J].东南大学学报:自然科学版,2010,40(5):1009-1012. [doi:10.3969/j.issn.1001-0505.2010.05.024]
更新日期/Last Update: 2010-09-20