[1]谢书珊,王志功,吕晓迎,等.神经信号再生专用微电子系统的设计[J].东南大学学报(自然科学版),2010,40(6):1157-1162.[doi:10.3969/j.issn.1001-0505.2010.06.006]
 Xie Shushan,Wang Zhigong,Lü Xiaoying,et al.Design of special microelectronic system chip for neural signal regeneration[J].Journal of Southeast University (Natural Science Edition),2010,40(6):1157-1162.[doi:10.3969/j.issn.1001-0505.2010.06.006]
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神经信号再生专用微电子系统的设计()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
40
期数:
2010年第6期
页码:
1157-1162
栏目:
电路与系统
出版日期:
2010-11-20

文章信息/Info

Title:
Design of special microelectronic system chip for neural signal regeneration
作者:
谢书珊1 王志功1 吕晓迎2 沈晓燕1 黄宗浩1 潘海仙2
1 东南大学射频与光电集成电路研究所,南京 210096; 2 东南大学生物电子学国家重点实验室,南京 210096
Author(s):
Xie Shushan1 Wang Zhigong1 Lü Xiaoying2 Shen Xiaoyan1 Huang Zonghao1 Pan Haixian2
1 Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China
2 State Key Laboratory of Bio-Electronics, Southeast University, Nanjing 210096,China
关键词:
微电子 神经信号 探测 噪声 功耗
Keywords:
microelectronics neural signal detecting noise power dissipation
分类号:
TN492;Q426
DOI:
10.3969/j.issn.1001-0505.2010.06.006
摘要:
根据神经束电信号的特点,提出一种适用于中枢神经束电信号探测放大和再激励的微电子系统设计方案,功能单元包括微弱神经电信号探测电路、交流信号耦合电路和神经束再激励电路.为面向生物体植入应用,系统设计主要考虑功耗、噪声和交流耦合输入等性能.另外,设计了2种运算放大器单元,分别是用于前置电路的低噪声、低功耗两级运算放大器和具有高增益、高驱动能力的输入输出全摆幅恒跨导折叠运算放大器.系统采用CSMC双层多晶硅双层金属(DPDM)标准0.5μm CMOS工艺设计完成.仿真和测试结果表明设计芯片实现了微弱低频电信号放大功能,可用于神经信号再生应用,功耗和体积满足生物体植入式器件的要求.
Abstract:
According to the features of neural signals, a microelectronic system is designed for central nervous signal detection and stimulation, and realized in CSMC’s 0.5μm CMOS(complementary metal-oxide-semiconductor transistor)technology. The main modules of the system include the weak neural signal detection circuit, the ac-coupled circuit, and the stimulating circuit. The requirments of the implantation use, the performance of power dissipation, the noise performance and the ac-coupled input are discussed in detail. Two operation amplifiers(OPAs)are used in the system. One is low-power low-noise two-stage OPA used for front-end circuit performance, and the other is constant-gm RTR(rail to rail)input and output OPA used for obtaining high gain and high driver. The results of simulation and test show that the system has the function of weak low-frequency singal detection and the potential of application in neural signal regeneration and body implantation.

参考文献/References:

[1] Wise K D,Sodagar A M,Yao Y,et al.Microelectrodes,microelectronics,and implantable neural microsystems[J].Proceedings of the IEEE,2008,96(7):1184-1202.
[2] Fuentes Romulo,Petersson Per,Siesser William B.Spinal cord stimulation restores locomotion in animal models of Parkinson’s disease[J].Science,2009,323(5921):1578-1582.
[3] Eversmann B,Jenkner M,Hofmann F,et al.A 128×128 CMOS biosensor array for extracellular recording of neural activity[J].IEEE J Solid-State Circuits,2003,38(12):2306-2317.
[4] 王志功,顾晓松,吕晓迎.电子系统辅助神经信道功能恢复方法及其装置:中国,ZL 200510135541.6[P].2008.
[5] Nielsen J H,Lehmann T.An implantable CMOS amplifier for nerve signals[C] //The 8th IEEE International Conference on Electronics,Circuits and Systems.Gyeonggi-do,Korea,2001,3:1183-1186.
[6] Vehkaoja A,Lekkala J.Wearable wireless biopotential measurement device[C] //26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.San Francisco,CA,USA,2004,1:2177-2179.
[7] Wang Y F,Wang Z G.A single-chip and low-power CMOS amplifier for neural signal detection[J].Chinese Journal of Semiconductors,2006,27(8):1490-1495.
[8] Harrison R R,Charles C.A low-power low-noise CMOS amplifier for neural recording application[J].IEEE J Solid-State Circuits,2003,38(6):958-965.
[9] Zarifi M H,Frounchi J,Farshchi S,et al.A low-power,low-noise neural-signal amplifier circuit in 90-nm CMOS[C] // 30th Annual International IEEE EMBS Conference.Vancouver,British Columbia,Canada,2008:2389-2392.
[10] 吴金,周震.一种前馈型全摆幅恒跨导准恒增益CMOS运放设计[J].电路与系统学报,2004,9(3):69-71.
  Wu Jin,Zhou Zhen.Design of rail-to-rail constant conductance and approximate constant-gain input stage of operational amplifiers[J].Journal of Circuits and Systems,2004,9(3):69-71.(in Chinese)

备注/Memo

备注/Memo:
作者简介: 谢书珊(1981—),男,博士生; 王志功(联系人),男,博士,教授,博士生导师,zgwang@seu.edu.cn.
基金项目: 国家自然科学基金资助项目(90307013, 90707005)、江苏省自然科学基金资助项目(BK2008032).
引文格式: 谢书珊,王志功,吕晓迎,等.神经信号再生专用微电子系统的设计[J].东南大学学报:自然科学版,2010,40(6):1157-1162. [doi:10.3969/j.issn.1001-0505.2010.06.006]
更新日期/Last Update: 2010-11-20