[1]王业清,史可丽,廖志新,等.提高中药疏水性抗肝炎有效成分花锚口山酮总苷溶出度[J].东南大学学报(自然科学版),2011,41(4):809-814.[doi:10.3969/j.issn.1001-0505.2011.04.029]
 Wang Yeqing,Shi Keli,Liao Zhixin,et al.Improving dissolution of antihepatitis-effective-ingredients total xanth-one glucosides of Halenia elliptica[J].Journal of Southeast University (Natural Science Edition),2011,41(4):809-814.[doi:10.3969/j.issn.1001-0505.2011.04.029]
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提高中药疏水性抗肝炎有效成分花锚口山酮总苷溶出度()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
41
期数:
2011年第4期
页码:
809-814
栏目:
生物医学工程
出版日期:
2011-07-20

文章信息/Info

Title:
Improving dissolution of antihepatitis-effective-ingredients total xanth-one glucosides of Halenia elliptica
作者:
王业清1史可丽1廖志新1纪兰菊2孙洪发2
(1东南大学化学化工学院,南京 211189)
(2中国科学院西北高原生物研究所,西宁 810001)
Author(s):
Wang Yeqing1Shi Keli1Liao Zhixin1Ji Lanju2Sun Hongfa2
(1 School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China)
(2 Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China)
关键词:
中药有效成分花锚总苷固体分散体溶出度扫描电子显微镜
Keywords:
effective ingredients of chinese herb medicines total glucosides of halenia elliptica solid dispersion dissolution scanning electron microscope
分类号:
R969.1
DOI:
10.3969/j.issn.1001-0505.2011.04.029
摘要:
针对某些中药有效成分因水溶性差而引起药物生物利用度低的问题,选取具有抗肝炎活性的花锚总苷为研究对象,运用熔融法或溶剂法分别制备了4种不同载体组成的花锚总苷固体分散体,通过HPLC方法测定溶出度.研究结果表明,聚乙二醇4000、聚乙二醇6000、泊洛沙姆188、聚乙烯基吡咯烷酮k30均能与花锚总苷制备固体分散体,相对于花锚总苷,固体分散体的溶出度都有明显提高,且随着载体比例的增加而增加,其中聚乙二醇6000-花锚总苷固体分散体(药载比6:1)将溶出度从花锚总苷的18.3%提高到92%.采用扫描电子显微镜对花锚总苷、各固体分散体及样品载体物理混合物的微观形态进行了观察,结果表明,花锚总苷与载体以有助于增强溶解性的低共溶物形式存在于固体分散体中.
Abstract:
Against the low bioavailability of the effective ingredients in many chinese herb medicines, solid dispersions (SDs) of 4 different carriers with antihepatitis total glucosides of halenia elliptica D. Don (ATH) were prepared by melt or solvent method, and the dissolution rate was determined by HPLC(high pressure liquid chromatography). According to the results, PEG4000, PEG6000, Poloxamer188 and PVPk30 can be used to prepare SD with ATH. Compared with ATH, the dissolution rate of SDs is increased obviously, and the dissolution rate become higher with the increase of carrier ratio. The dissolution rate of PEG6000-ATH SD may increase up to 92% (carrier drug ratio 6:1), in contrast it is only 18. 3% in ATH. Microscopical morphology of ATH, SDs and physical mixture samples was analyzed by scanning electron microscope (SEM), the results indicate that the drug and carriers exist as eutectic which is conducive to a high dissolution rate in the SDs.

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备注/Memo

备注/Memo:
作者简介:王业清(1986—),男,硕士生;廖志新(联系人),男,博士,教授,博士生导师,zxliao@seu.edu.cn.
基金项目:国家自然科学基金资助项目(30770233)、青海省重点攻关资助项目(2008-G-136).
引文格式: 王业清,史可丽,廖志新,等.提高中药疏水性抗肝炎有效成分花锚口山酮总苷溶出度[J].东南大学学报:自然科学版,2011,41(4):809-814.[doi:10.3969/j.issn.1001-0505.2011.04.029]
更新日期/Last Update: 2011-07-20