# [1]吴卫平,陆荣生,倪中华.微型核磁共振芯片平面微型线圈设计与信噪比分析[J].东南大学学报(自然科学版),2011,41(6):1208-1212.[doi:10.3969/j.issn.1001-0505.2011.06.016] 　Wu Weiping,Lu Rongsheng,Ni Zhonghua.Design and signal to noise ratio analysis of planar microcoil for micro-NMR chip[J].Journal of Southeast University (Natural Science Edition),2011,41(6):1208-1212.[doi:10.3969/j.issn.1001-0505.2011.06.016] 点击复制 微型核磁共振芯片平面微型线圈设计与信噪比分析() 分享到： var jiathis_config = { data_track_clickback: true };

41

2011年第6期

1208-1212

2011-11-20

## 文章信息/Info

Title:
Design and signal to noise ratio analysis of planar microcoil for micro-NMR chip

(东南大学机械工程学院,南京 211189)
Author(s):
(School of Mechanical Engineering, Southeast University, Nanjing 211189, China)

Keywords:

TP212.3
DOI:
10.3969/j.issn.1001-0505.2011.06.016

Abstract:
A planar microcoil applied in micro nuclear magnetic resonance(NMR) chip was designed. When the main magnetic field is 0. 7 T and the aspect ratio of planar microcoil is 1, based on the mathematical model of signal to noise ratio(SNR) and taking the critical width of coil as twice the skin depth, the relation between SNRs and various geometric parameters were analysed for planar microcoil with sub-millimetric diameter. Result shows that reducing the diameter of planar microcoil increases the SNR; sample should be located as close as possible to the planar microcoil provided the radiofrequency homogeneity is not decreased heavily; high SNR is obtained when the space of adjacent wires is equal to the wire width; SNR behaves good when the width of planar microcoil is twice the skin depth. At last, geometric parameters of planar microcoil are determined: radius of coil is 120μm, the wire width is 24μm, the space of adjacent wires is 24μm, and the number of turns is 3.

## 参考文献/References:

[1] Lacey M E, Subramanian R, Olson D L, et al.High-resolution NMR spectroscopy of sample volumes from 1 nL to 10 μL[J].Chemical Reviews,1999,99(10):3133-3152.
[2] Harel E.Lab-on-a-chip detection by magnetic resonance methods[J].Progress in Nuclear Magnetic Resonance Spectroscopy,2010,57(3):293-305.
[3] Harel E.Magnetic resonance detection: spectroscopy and imaging of lab-on-a-chip[J].Lab on a Chip,2009,9(1):17-23.
[4] Carrieri D, McNeely K, de Roo A C, et al.Identification and quantification of water-soluble metabolites by cryoprobe-assisted nuclear magnetic resonance spectroscopy applied to microbial fermentation[J].Magnetic Resonance in Chemistry,2009,47:138-146.
[5] Neuberger T, Webb A.Radiofrequency coils for magnetic resonance microscopy[J].Nmr in Biomedicine,2009,22(9):975-981.
[6] Hoult D I, Richards R E.Signal-to-noise ratio of nuclear magnetic-resonance experiment[J].Journal of Magnetic Resonance,1976,24(1):71-85.
[7] Olson D L, Peck T L, Webb A G, et al.High-resolution microcoil 1H-NMR for mass-limited, nanoliter-volume samples[J].Science,1995,270(5244):1967-1970.
[8] Peck T L, Magin R L, Lauterbur P C.Design and analysis of microcoils for nmr microscopy[J].Journal of Magnetic Resonance Series B,1995,108(2):114-124.
[9] Lee H, Sun E, Ham D, et al.Chip-NMR biosensor for detection and molecular analysis of cells[J].Nature Medicine,2008,14(8):869-874.
[10] Peck T L, Magin R L, Kruse J, et al.NMR microspectroscopy using 100 μm planar RF coils fabricated on gallium arsenide substrates[J].Ieee Transactions on Biomedical Engineering,1994,41(7):706-709.
[11] Trumbull J D, Glasgow I K, Beebe D J, et al.Integrating microfabricated fluidic systems and NMR spectroscopy[J].Ieee Transactions on Biomedical Engineering,2000,47(1):3-7.
[12] Massin C, Boero C, Vincent F, et al.High-Q factor RF planar microcoils for micro-scale NMR spectroscopy[J].Sensors and Actuators a-Physical,2002,97-98:280-288.
[13] Massin C, Vincent F, Homsy A, et al.Planar microcoil-based microfluidic NMR probes[J].Journal of Magnetic Resonance,2003,164(2):242-255.
[14] Ehrmann K, Gersbach M, Pascoal P, et al.Sample patterning on NMR surface microcoils[J].Journal of Magnetic Resonance,2006,178(1):96-105.
[15] Eroglu S, Gimi B, Roman B, et al.NMR spiral surface microcoils: design, fabrication, and imaging[J].Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering,2003,17B(1):1-10.
[16] Wensink H, Hermes D C, van den Berg A. High signal to noise ratio in low field NMR on chip, simulations and experimental results [C]//Mems 2004: 17th Ieee International Conference on Micro Electro Mechanical Systems, Technical Digest.Maastricht, Netherlands,2004:407-410.
[17] 李晓南,赵武贻,王明,等.纳升级生化样品核磁共振微检测用高信噪比平面微线圈的设计[J].传感技术学报,2008,21(3):397-400.
Li Xiaonan,Zhao Wuyi,Wang Ming,et al.Design of planar spiral microcoil with high SNR for nano-liter bio-chemical sample in NMR detection[J].Chinese Journal of Sensors and Actuators, 2008,21(3):397-400.(in Chinese)
[18] 吴英,江永清,周兆英,等.MRI微型RF接收线圈的设计与制作[J].半导体光电,2006,27(5):556-559.
Wu Ying,Jiang Yongqing,Zhou Zhaoying,et al.Design and fabrication of micro RF coil for MRI[J].Semiconductor Optoelectronics, 2006,27(5):556-559. (in Chinese)
[19] Prasad P V. Magnetic resonance imaging: methods and biologic applications[M].Totowa,New Jersey USA:Humana Press,2006:3-57.
[20] Levitt M H. Spin dynamics: basics of nuclear magnetic resonance[M]. Chichester, New York,USA:John Wiley & Sons,2008:5-105.
[21] Hoult D I, Lauterbur P C.Sensitivity of the zeugmatographic experiment involving human samples[J].Journal of Magnetic Resonance,1979,34(2):425-433.
[22] Webb A G.Microcoil nuclear magnetic resonance spectroscopy[J].Journal of Pharmaceutical and Biomedical Analysis,2005,38(5):892-903.
[23] 赵凯华,陈熙谋.电磁学[M].北京:高等教育出版社,2003:94-99.
[24] 秦曾煌.电工学(上)[M].5版.北京:高等教育出版社,1999:94-95.
[25] Butterworth S.Effective resistance of inductance coils at radio frequencies[J].Experimental Wireless and the Wireless Engineer,1926,3:203-210,309-316,417-424,483-492.