[1]尹双青,吉民,姚日生.Dex/PVA复合凝胶的制备及其对辅酶A的控制释放[J].东南大学学报(自然科学版),2011,41(6):1330-1336.[doi:10.3969/j.issn.1001-0505.2011.06.037]
 Yin Shuangqing,Ji Min,Yao Risheng.Preparation of Dex/PVA composite gel and its controlled release of coenzyme A[J].Journal of Southeast University (Natural Science Edition),2011,41(6):1330-1336.[doi:10.3969/j.issn.1001-0505.2011.06.037]
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Dex/PVA复合凝胶的制备及其对辅酶A的控制释放()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
41
期数:
2011年第6期
页码:
1330-1336
栏目:
化学化工
出版日期:
2011-11-20

文章信息/Info

Title:
Preparation of Dex/PVA composite gel and its controlled release of coenzyme A
作者:
尹双青12吉民1姚日生3 
(1东南大学化学化工学院,南京 211189)
(2马鞍山丰原制药有限公司,马鞍山 243011)
(3合肥工业大学医学工程学院,合肥 230009)
Author(s):
Yin Shuangqing12Ji Min1Yao Risheng3
(1 School of Chemistry and Chemical Engineering,Southeast University,Nanjing 211189,China)
(2 Maanshan Fengyuan Pharmaceutical Co. Ltd., Maanshan 243011,China)
(3 School of Medical Engineering,Hefei University of Technology,Hefei 230009,China)
关键词:
Dex/PVA复合凝胶 辅酶A 控制释放 温度敏感性
Keywords:
Dex/PVA composite gel coenzyme A controlled release temperature sensitivity
分类号:
TQ460.6
DOI:
10.3969/j.issn.1001-0505.2011.06.037
摘要:
以葡聚糖-20(Dex)为原料,运用冷冻干燥法,在水相体系中制得粒径为100~200nm的微凝胶.采用微波-冻融、冷冻干燥法在聚乙烯醇(PVA)凝胶中嵌入Dex微凝胶,生成Dex/PVA的复合凝胶,并用红外光谱、X-粉末衍射和透射电镜表征了Dex微凝胶的结构,用扫描电镜表征了Dex/PVA复合凝胶的微观形貌.溶胀试验和力学性能测试表明, Dex/PVA复合凝胶具有Dex微凝胶的环境响应性和PVA凝胶的力学性能.在不同温度、不同pH值条件下,用复合凝胶在辅酶A质量分数为0.80%的缓冲溶液中制得样品进行药物控制释放试验.结果显示,复合凝胶对辅酶A的控制释放具有温度和pH值敏感性,在温度10℃,pH=4.5的磷酸缓冲溶液中,含有30%Dex微凝胶的PVA复合凝胶能较好地控制辅酶A的释放,释药动力学方程为Rc=100t0.27/(1.47+6.56t-0.23),R2=0.9989.
Abstract:
Using Dextran(Dex)-20 as raw materials, Dex microgel structures with diameter of 100 to 200nm was prepared in water base by freeze-drying method. Then a new polyvinyl alcohol(PVA) hydrogels dressing with dextran microgel structures (Dex/PVA) were further designed and prepared by the microwave-assisted freezing-thawing method combined with freeze-drying method. The structure of the Dex microgels was characterized by infrared spectroscopy, powder X-ray diffraction and transmission electron microscopy. The microstructure of Dex/PVA was identified by scanning electron microscopy. It was found from mechanical properties and swelling tests that the Dex/PVA gel could perfectly integrate the good environmental responsiveness of Dex microgel and the high mechanical property of PVA macro-gel. The drug release experiment was carried out at different temperatures and different pH using coenzyme A as the model drug with a concentration of 0. 80% in the buffer solution. The results show that the release-control property is temperature-sensitive and pH-sensitive. In phosphate buffer solution with temperature 10℃ and pH4. 5, the Dex/PVA composite gel containing 30% Dex microgel demonstrates a good release-control property for coenzyme A, The drug release processes accord with the kinetics equation Rc=100t0. 27/(1. 47+6. 56t-0. 23), R2=0. 9989.

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备注/Memo

备注/Memo:
作者简介: 尹双青(1969—),男,博士生,教授级高级工程师; 吉民(联系人),女,教授,博士生导师,jimin@seu.edu.cn.
基金项目: 科技部技术创新基金资助项目(10C26213401647).
引文格式: 尹双青,吉民,姚日生.Dex/PVA复合凝胶的制备及其对辅酶A的控制释放[J].东南大学学报:自然科学版,2011,41(6):1330-1336. [doi:10.3969/j.issn.1001-0505.2011.06.037]
更新日期/Last Update: 2011-11-20