[1]张丽,朱晓璐,倪中华.应用于类球体细胞电旋转分析中的介电参数求解算法[J].东南大学学报(自然科学版),2012,42(2):280-285.[doi:10.3969/j.issn.1001-0505.2012.02.017]
 Zhang Li,Zhu Xiaolu,Ni Zhonghua.Dielectric parameter solving algorithm in electrorotation analysis of spherical cells[J].Journal of Southeast University (Natural Science Edition),2012,42(2):280-285.[doi:10.3969/j.issn.1001-0505.2012.02.017]
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应用于类球体细胞电旋转分析中的介电参数求解算法()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
42
期数:
2012年第2期
页码:
280-285
栏目:
计算机科学与工程
出版日期:
2012-03-20

文章信息/Info

Title:
Dielectric parameter solving algorithm in electrorotation analysis of spherical cells
作者:
张丽 朱晓璐 倪中华
东南大学机械工程学院, 南京 211189
Author(s):
Zhang Li Zhu Xiaolu Ni Zhonghua
School of Mechanical Engineering, Southeast University, Nanjing 211189, China
关键词:
介电参数 粒子群优化 电旋转 白细胞
Keywords:
dielectric parameter particle swarm optimization electrorotation leukocyte
分类号:
TP391
DOI:
10.3969/j.issn.1001-0505.2012.02.017
摘要:
根据薄膜理论建立了一种面向类球体细胞的单壳介电模型,分析了细胞在电旋转静流场中的受力,并由旋转力矩和斯托克斯流体阻力矩平衡原理,推导得到细胞各层介电参数方程组.利用引入压缩因子的粒子群优化算法求解细胞的介电参数,并讨论了压缩因子的变化对求解结果的影响.以Granulocytes白细胞为例进行算法验证,得到细胞膜的电导率和相对介电常数分别为7.25μS/m和10.3,细胞质的电导率和相对介电常数分别为0.487 S/m和136,且压缩因子的变化仅影响各组解的搜索概率,加速系数为2.015时所需解的搜索概率达到最高值.算法结果与白细胞介电参数的经验数据相吻合,表明该算法具有较高的精确性和稳定性.
Abstract:
A dielectric model with single concentric shell of spherical cells is established based on film theory. The forces of the cells in a static flow field under the action of electrorotation are analyzed, and the force equilibrium equations are derived to obtain dielectric parameters of each shell by the balance of the rotating torque and the Stokes fluid drag torque. Then, the particle swarm optimization algorithm improved with the constriction factor is used to solve the equations. The influence of the change in the constriction factor on the solution results is also discussed. This algorithm is validated with Granulocytes as an example. The calculated membrane conductivity, membrane relative permittivity, cytoplasm conductivity and cytoplasm relative permittivity are 7.25μS/m, 10.3, 0.487 S/m and 136, respectively. Besides, the change in the constriction factor just affects the search probability of each solution, and the search probability needed gets the highest value with the acceleration factor of 2.015. The calculated results are consistent with the empirical data, showing that the proposed algorithm can obtain high accuracy and stability.

参考文献/References:

[1] Arnold W M,Zimmermann U.Electro-rotation:development of a technique for dielectric measurements on individual cells and particles [J].Journal of Electrostatics,1988,21(2/3):151-191.
[2] Sancho M,Martínez G,Muñoz S,et al.Interaction between cells in dielectrophoresis and electrorotation experiments [J].Biomicrofluidics,2010,4(2):1-11.
[3] Voyer D,Frénéa-Robin M,Buret F,et al.Improvements in the extraction of cell electric properties from their electrorotation spectrum [J].Bioelectrochemistry,2010,79(1):25-30.
[4] Yang J,Huang Y,Wang X,et al.Dielectric properties of human leukocyte subpopulations determined by electrorotation as a cell separation criterion [J].Biophysical Journal,1999,76(6):3307-3314.
[5] Gascoyne P R C,Becker F F,Wang X B.Numerical analysis of the influence of experimental conditions on the accuracy of dielectric parameters derived from electrorotation measurements [J].Bioelectrochemistry and Bioenergetics,1995,36(2):115-125.
[6] Mishima B,Mimura K A,Takahara Y,et al.On-line monitoring of cell concentrations by dielectric measurements[J].Journal of Fermentation and Bioengineering,1991,72(4):291-295.
[7] Harris C M,Todd R W,Bungard S J,et al.Dielectric permittivity of microbial suspensions at radio frequencies:a novel method for the real-time estimation of microbial biomass [J].Enzyme Microb Technol,1987,9(3):181-186.
[8] Takashima S.Passive electrical properties and voltage dependent membrane capacitance of single skeletal muscle fibers [J].Pflugers Arch Eur J Physiol,1985,403(2):197-204.
[9] Asami K,Takashima S.Membrane admittance of cloned muscle cells in culture:use of a micropipette technique [J].Biochim Biophys Acta,1994,1190(1):129-136.
[10] Jones T B.Basic theory of dielectrophoresis and electrorotation [J].IEEE Engineering in Medicine and Biology Magazine,2003,22(6):33-42.
[11] Gawad S,Cheung K,Seger U,et al.Dielectric spectroscopy in a micromachined flow cytometer:theoretical and practical considerations [J].Lab Chip,2004,4(3):241-251.
[12] Holmes D,Green N G,Morgan H.Microdevices for dielectrophoretic flow-through cell separation [J].IEEE Engineering in Medicine and Biology Magazine,2003,22(6):85-89.
[13] 杨维,李歧强.粒子群优化算法综述[J].中国工程科学,2004,6(5):87-94.
  Yang Wei,Li Qiqiang.Survey on particle swarm optimization algorithm [J].Engineering Sciences,2004,6(5):87-94.(in Chinese)
[14] 陈长忆,叶永春.基于粒子群算法的非线性方程组求解[J].计算机应用与软件,2006,23(5):137-139.
  Chen Changyi,Ye Yongchun.Solving nonlinear systems of equations based on particle swarm optimization[J].Computer Applications and Software,2006,23(5):137-139.(in Chinese)

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备注/Memo

备注/Memo:
作者简介: 张丽(1987—),女,硕士生; 倪中华(联系人),男,博士,教授,博士生导师,nzh2003@seu.edu.cn.
基金项目: 国家自然科学基金重大研究计划(培育)资助项目(91023024)、教育部博士研究生学术新人奖资助项目、江苏省普通高校研究生科研创新计划资助项目(CX10B_062Z)、东南大学优秀博士学位论文基金资助项目.
引文格式: 张丽,朱晓璐,倪中华.应用于类球体细胞电旋转分析中的介电参数求解算法[J].东南大学学报:自然科学版,2012,42(2):280-285. [doi:10.3969/j.issn.1001-0505.2012.02.017]
更新日期/Last Update: 2012-03-20