[1]沈晓燕,王志功,吕晓迎,等.基于微电子神经桥实现大鼠运动功能重建的实验研究[J].东南大学学报(自然科学版),2012,42(5):843-847.[doi:10.3969/j.issn.1001-0505.2012.05.009]
　Shen Xiaoyan,Wang Zhigong,Lü Xiaoying,et al.Experimental research on rebuilding motive functions of rat using microelectronic neural bridge[J].Journal of Southeast University (Natural Science Edition),2012,42(5):843-847.[doi:10.3969/j.issn.1001-0505.2012.05.009]
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基于微电子神经桥实现大鼠运动功能重建的实验研究()
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《东南大学学报(自然科学版)》[ISSN:1001-0505/CN:32-1178/N]

卷:
42
期数:
2012年第5期
页码:
843-847
栏目:
电路与系统
出版日期:
2012-09-20

文章信息/Info

Title:
Experimental research on rebuilding motive functions of rat using microelectronic neural bridge
作者:
沈晓燕1; 2;  王志功2;  吕晓迎3;  姜正林4;  赵鑫泰2;  黄宗浩2
1 南通大学电子信息学院, 南通 226019; 2 东南大学射频与光电集成电路研究所, 南京 210096; 3 东南大学生物电子学国家重点实验室, 南京 210096; 4 南通大学航海医学研究所, 南通 226001
Author(s):
Shen Xiaoyan1; 2;  Wang Zhigong2;  Lü Xiaoying3;  Jiang Zhenglin4;  Zhao Xintai2;  Huang Zonghao2
1 School of Electronic Information, Nantong University, Nantong 226019, China
2 Institute of RF and OE-ICs, Southeast University, Nanjing 210096, China
3 State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
4 Institute of Nautical Medicine, Nantong University, Nantong 226001, China
关键词:
微电子神经桥;  神经功能重建;  信号再生;  相干性分析
Keywords:
microelectronic neural bridge;  neural functional rebuilding;  signal regeneration;  coherence analysis
分类号:
TN4;Q426
DOI:
10.3969/j.issn.1001-0505.2012.05.009
摘要:
设计了一种大鼠神经信道桥接、信号再生和功能重建的实验方案.首先对脊髓适当位置进行功能电激励,诱发控制左腿动作的坐骨神经信号; 然后,将此信号作为微电子神经桥的信号源,经微电子神经桥放大处理后施加于离断的右腿坐骨神经远端,从而使瘫痪的右腿产生动作.对控制左腿动作的坐骨神经信号和再生后的右腿神经信号进行相关性分析,结果表明,与再生前的信号相比,再生后的信号在时间上存在延迟,且两者的相干函数值为0.89,符合因果关系.这种设计方案既避免了因生物体组织传导可能引入的伪迹,又克服了因控制运动的神经信号中编、解码未知所造成的困难; 此外,运用控制动作的原始神经信号作为控制信号源,使重建更精细、协调的动作行为成为可能.
Abstract:
An experimental scheme is designed to realize the rat’s sciatic nerve bridge, signal regeneration and function rebuilding. First, by functional electrical stimulation at the proper sites of spinal cord, sciatic nervous signals related to the movements of the left leg are evoked and used as the signal sources of the microelectronics neural bridge(MENB).Then, the signals that are amplified and processed by MENB are supplied on the distal stump of the right interrupted sciatic nerve, and movements are regenerated. The relationships between the source nervous signals and the regenerated nervous signals are investigated by using coherence analysis. The results show that the regenerated nervous signals are delayed in relation to the source nervous signals and the cross-correlation function reaches the value of 0.89, which are consistent with causality. This special experimental scheme can not only avoid the artifact introduced by transmission of organization, but also overcome the difficulties owing to the unknown of the coding and decoding of the neural signals which control movements. Besides, precise and coordinated movements can be rebuilt when the original nervous signals are used as the source signals to control the objective limb.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介: 沈晓燕(1969—),女,博士,副教授; 王志功(联系人),男,博士,教授,博士生导师,zgwang@seu.edu.cn.
基金项目: 国家自然科学基金资助项目(90707005,61001046)、江苏省高校自然科学研究计划资助项目(11KJB510022,11KJB510023)、东南大学生物电子学国家重点实验室开放研究基金资助项目(2011E05).
引文格式: 沈晓燕,王志功,吕晓迎,等.基于微电子神经桥实现大鼠运动功能重建的实验研究[J].东南大学学报:自然科学版,2012,42(5):843-847. [doi:10.3969/j.issn.1001-0505.2012.05.009]
更新日期/Last Update: 2012-09-20