[1]朱健,白曈,李宝生舒华忠,等.肿瘤放疗并发症概率预测模型参数拟合方法[J].东南大学学报(自然科学版),2015,45(2):256-259.[doi:10.3969/j.issn.1001-0505.2015.02.011] 　Zhu Jian,Bai Tong,Li BaoshengShu Huazhong,et al.Parameter fitting method of NTCP predictive model in radiation oncology[J].Journal of Southeast University (Natural Science Edition),2015,45(2):256-259.[doi:10.3969/j.issn.1001-0505.2015.02.011] 点击复制 肿瘤放疗并发症概率预测模型参数拟合方法() 分享到： var jiathis_config = { data_track_clickback: true };

45

2015年第2期

256-259

2015-03-20

文章信息/Info

Title:
Parameter fitting method of NTCP predictive model in radiation oncology

1东南大学影像科学与技术实验室, 南京 210096; 2山东省肿瘤防治研究院, 济南 250117; 3雷恩第一大学信号与图像实验室, 法国雷恩 35510
Author(s):
1Laboratory of Image Science and Technique, Southeast University, Nanjing 210096, China
2Shandong Cancer Hospital and Institute, Jinan 250117, China
3Laboratoire Traitement du Signal et de l’Image, Université de Rennes 1, Rennes 35510, France

Keywords:

TP391.9
DOI:
10.3969/j.issn.1001-0505.2015.02.011

Abstract:
To establish the population specific NTCP(normal tissue complication probability)prediction model in radiation oncology, a parameter fitting method is proposed. First, the maximum likelihood function is constructed based on the characteristic of the NTCP model. Then, the deterministic optimization method and the stochastic optimization method are used to optimize the maximum likelihood function, respectively. The time cost and the optimization results are analyzed to find the better method for fitting the parameters of the NTCP model. The experimental results show that the maximum likelihood function for fitting the parameters of the NTCP model is non-convex, indicating that there exist the local optimal solutions. The genetic algorithm is the most stable optimization algorithm for fitting the NTCP model, and the running time is less than that of the simulated annealing algorithm. In this algorithm, the global optimal solutions, which are regarded as the parameters of the NTCP model, can be obtained after each optimization. The proposed method can help the researchers in radiation oncology establish the population specific NTCP predictive models based on clinical follow-ups.

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